The normal range is .87 to 1.52 mmol/L. J Biol Chem. Although not all of these side effects may occur, if they do occur they may need medical attention. These are minerals that the body needs to function normally. Recent studies, however, suggest that this may not be the case. By using Verywell Health, you accept our, Phytic Acid: Benefits, Side Effects, Dosage, and Interactions, Watch These Nutrients If You Have Diabetes-Related Kidney Disease, What You Need to Know About Calcium and Vitamin D Supplements, X-linked Hypophosphatemia: Symptoms, Causes, Diagnosis, and Treatment, Lactase supplements can help those with lactose intolerance, Food Nutrition Board of the Institute of Medicine, people in intensive care units (up to 33.9 percent), people involved in major trauma, such as a severe burn (75 percent), children zero to six months: 100 milligrams per day (mg/day), adolescents and teens nine to 18 years: 1,250 mg/day, pregnant or lactating women 18 and under: 1,250 mg/day, pregnant or lactating women over 18: 700 mg/day, Pumpkin or squash seeds: 676 mg per 1/4-cup serving, Sunflower sees: 343 mg per 1/4-cup serving, Canned sardines in oil: 363 mg per 2.5-ounce serving, Hard cheese: 302 mg per 1.5-ounce serving, Lentils (cooked): 264 mg per 3/4-cup serving, Canned salmon: 247 mg per 2.5-ounce serving, Canned tuna in water: 104 mg per 2.5-ounce serving. ... [OTC]) medicines and herbal or vitamin supplements. Hypophosphatemia may also be caused by the overuse of diuretics (water pills) or phosphate-lowering drugs used during kidney dialysis. Excessive intake of phosphorus (or phosphate) supplements may worsen conditions such as heart disease, pancreatitis, rickets, osteomalacia (softening of bones), high blood pressure, and liver and kidney disease. Gastrointestinal. Phosphorus is used for Nutritional Deficiencies, Increased Blood Calcium Levels, Hyperparathyroidism etc. Phosphate may interact with some pharmaceutical and over-the-counter medications. Find everything you need to know about Potassium Phosphate And Sodium Phosphate (PHOS-Nak), including what it is used for, warnings, reviews, side effects… Call your doctor for medical advice about side effects. Other symp… Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Side Effects. Excessively high levels of phosphorus in the blood, although rare, can combine with calcium to form deposits in soft tissues, such as muscle. Moreover, increased phosphate intake was not associated with toxicity. Talk with your physician before taking phosphorus supplements if … Symptoms may include rash, itching, muscle cramps, spasms, bone or joint pain, or numbness and tingling around the mouth. Phosphorus supplements that contain sodium can cause edema in people with heart failure or cirrhosis. Don’t take this supplement if you’re pregnant or nursing, and take only the recommended amount to prevent the following adverse side effects: red, itchy, irritated skin from continual skin contact; loss of appetite, nausea or vomiting; other gastrointestinal problems and frequent urination. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In the past, there was a concern that consuming too much phosphate could throw off this fine-tuned balance, drawing calcium from bone and increasing the risk of osteoporosis (bone mineral loss). How to Use It Phosphorus supplements are unnecessary. Portions of this document last updated: Oct. 01, 2020. According to Food Nutrition Board of the Institute of Medicine, the recommended dietary intake (RDI) of phosphorus from all sources varies by age and pregnancy status, as follows: Dosages exceeding 3,000 to 3,500 mg/day are generally considered excessive and may adversely affect the balance of macro and trace minerals in your blood. Side Effects of P5P. It is also water-soluble, meaning the body releases it in urine. However, certain types of medical conditions can make your body inefficient at removing extra phosphorus from the blood, which can result in a condition called hyperphosphatemia. Trautvetter, U.; Distcheid, B.; Jahreis, G. et al. What are the side effects and safety precautions of taking a phosphorus supplement? Phosphorus is also considered a macromineral (alongside calcium, sodium, magnesium, potassium, chloride, and sulfur) in that you need more of it than trace minerals like iron and zinc. Nutrients. Allergies to phosphate are rare, but it's still important to call your doctor or seek emergency care if you experience rash, hives, shortness of breath, rapid heartbeat, or swelling of the face, throat, or tongue after taking a phosphate supplement. Most people get all the phosphorus they need from diet. Though this is not true with all stones. Phosphate supplements are considered safe if taken as prescribed. People with chronic kidney disease may need to avoid phosphate supplements. Certain drugs may cause decreases in phosphorus levels in the blood, including: Other drugs may cause phosphorus levels to rise excessively, including: If you are being treated with any of these medications, you should not take phosphate supplements without first speaking with your doctor. Calcium phosphate — which you find as tricalcium phosphate in supplements — contains close to 39 percent elemental calcium. According to the current research, high doses of phosphate increase bone mass density (BMD) and bone mass content (BMC) while decreasing the risk of osteoporosis in adults with adequate calcium intake. You may report side effects to the FDA at 1-800-FDA-1088. Excess phosphorus can also affect urine acidity and lead to the dislodgement of a previously undiagnosed kidney stone. Phosphate is also included in many multivitamin/mineral supplements as well as co-formulated supplements designed specifically for bone health. Along with its needed effects, potassium phosphate may cause some unwanted effects. You can also get too much phosphorus, a condition called hyperphosphatemia, if you take too much of the supplement phosphate. In addition, individuals who suffer from Addison's disease or disorders of the thyroid, lung and liver may be more likely to accumulate a high concentration of phosphorus in their blood if they take phosphorus supplements. Any excess phosphate in the blood is excreted either in urine or stool. Unlike certain micronutrients, the body cannot produce phosphorus on its own. Call your doctor for medical advice about side effects. Increasing the acidity with phosphate may only promote, rather than inhibit, their growth. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. 2015;14:28. 2018;10(7):936. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. James Myhre is an American journalist and HIV educator. Phosphorus is an essential mineral found in every cell of the human body. Most multiple vitamin-mineral supplements do not contain phosphorus for this reason. If you have any questions about this, check with your health care professional. Outside of severe kidney dysfunction, hyperphosphatemia is extremely rare. For U.S.— Recommended Dietary Allowances (RDAs) are the amount of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. Phosphate supplement may contain a large amount of sodium. Human Urinary Composition Controls Antibacterial Activity of Siderocalin. However, UTIs are more common in women with hypercalcemia (abnormally high calcium) as the increased urinary calcium promoted bacterial growth. Brunelli, S. and Goldfarb, S. Hypophosphatemia: Clinical Consequences and Management. The rest is freely circulating in the bloodstream to facilitate other biological functions. It is also believed to enhance athletic performance and strength, although there is little clinical evidence to support this claim. Supplements can help you meet your daily needs if your diet isn't quite cutting it. Side effects from phosphorus intake are rare because healthy kidneys help remove extra phosphate from your body to keep your blood levels in balance. Phosphorus isn’t commonly supplemented, even though it’s the second most plentiful mineral in our bodies, after calcium. Around 85 percent of phosphorus in the human body is stored in bone. Lee, A. and Cho, S. Association between phosphorus intake and bone health in the NHANES population. Beyond this, it may potentially cause: Phosphate injections are only given in a healthcare setting under the direction of a qualified specialist. He operates a private practice in Santa Monica, California. All rights reserved. To ensure quality and safety, only buy supplements that have been voluntarily submitted for testing by an independent certifying body like the United States Pharmacopeia (USP), ConsumerLab, of NSF International. Phosphate supplements are sometimes used to make the urine more acidic. Phosphorus in supplements is usually in the form of phosphate salts (e.g., dipotassium phosphate or disodium phosphate) or phospholipids (e.g., phosphatidylcholine or phosphatidylserine). Side Effects Phosphorus is so readily available in the food supply, so deficiency is rare. Side effects requiring immediate medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. For phosphate supplement: Adults—One or two tablets four times a day. You may report side effects to Health Canada at 1-866-234-2345. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. However, many people have no side effects or only have minor side effects. But stay on the safe side and look for supplements made from plants. This content does not have an Arabic version. Applies to potassium phosphate: intravenous solution. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Belly pain. Phosphorus also regulates how much calcium is in the body and how much is excreted in urine. Dipotassium phosphate is declared “generally recognized as safe (GRAS)” by the U.S. Food and Drug Administration (FDA). A deficiency of phosphorus is usually accompanied by hypophosphatemia, or low blood phosphate levels, which can affect every organ system of the body and may lead to muscle weakness, bone pain, fractures, seizures, and respiratory failure. Although not all of these side effects may occur, … Washington, D.C.: National Academies Press (US). Pyridoxal phosphate or P-5-P is the active form of vitamin B6, a crucial nutrient for physical and mental health. Injectable phosphate is sometimes used to treat severe hypophosphatemia. In addition, phosphorus additives are used in many soft drinks and packaged foods. Injections are generally indicated when the blood phosphorus level drops below .4 millimoles per liter (mmol/L). 2015;290:15949-60. What are some other side effects of Sodium Phosphates Tablets? Although not all of these side effects may occur, if they do occur they may need medical attention. JASN. Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, as well as an herbalist and integrative medicine doctor. it is more associated with the failure to clear phosphorus from the body rather than with the use of phosphate supplements. Bloating. Doing so helps ensure that cells and tissues are properly maintained, repaired, and replaced as they age. High doses can lead to headaches, nausea, dizziness, diarrhea, and vomiting. These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. Along with its needed effects, a medicine may cause some unwanted effects. The best dietary sources of phosphorus include dairy products, meat, poultry, fish, and cereal products. A 2015 study published in the Nutrition Journal proved this wasn't the case. Although the main function of phosphorus is to build and maintain bones and teeth, it also plays a major role in the formation of DNA and RNA (the genetic building blocks of the body). Phosphorus is one of 16 essential minerals. Dipotassium Phosphate Side Effects. Drug information provided by: IBM Micromedex. DOI: 10.1186/s12937-015-0017-0. The excessive intake of phosphate may interfere with the body's ability to use iron, calcium, magnesium, and zinc. Due to this, phosphate is rarely taken on its own but rather as part of a multivitamin/mineral supplement. Phosphorus also plays a key role in metabolism (the conversion of calories and oxygen to energy), muscle contraction, heart rhythm, and the transmission of nerve signals. These side effects may go away during treatment as your body adjusts to the medicine. Beyond the prevention or treatment of phosphorus deficiency, a phosphate supplement may offer specific health benefits, particularly in older adults and people prone to urinary tract infections (UTIs). As a supplement, P-5-P is promoted to deliver greater benefits with fewer side effects, but there’s no clinical evidence to back this up. The best food sources for phosphorus are meat, dairy, oily fish, and seeds. Drug information provided by: IBM Micromedex. All drugs may cause side effects. Phosphate supplements are vulnerable to extreme heat, humidity, and ultraviolet (UV) radiation. ISBN-10: 0-309-06350-7ISBN-10: 0-309-06403-1. Advertising revenue supports our not-for-profit mission. Side effects include diarrhea and stomach cramps . Phosphorus works with calcium to help build healthy bone and teeth. According to a study from Harvard Medical School, phosphorus deficiency is most commonly seen in: Low phosphorus can also affect people with certain diseases or medical conditions, including Cushing's disease, hypothyroidism, parathyroid disease, vitamin D deficiency, and malnutrition. This site complies with the HONcode standard for trustworthy health information: verify here. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Phosphate Supplement (Oral Route, Parenteral Route), FREE book offer – Mayo Clinic Health Letter, decrease in amount of urine or in frequency of urination, numbness, tingling, pain, or weakness in hands or feet, shortness of breath or troubled breathing. However, too much dicalcium phosphate, or dicalcium phosphate taken in conjunction … Allergies to phosphate are rare, but it's still important to call your doctor or seek emergency care if you experience rash, hives, shortness of breath, rapid heartbeat, or swelling of the face, throat, or tongue after taking a phosphate supplement. Never used expired supplements or supplements that are discolored or deteriorating, no matter the "use-by" date. Primary information, health benefits, side effects, usage, and other important details Creatinol O-Phosphate (COP) is a synthetic analogue of creatine that was created as a cardioprotective drug, and it appears to be helpful against arrythmia and aid the integrity of cardiac tissue following injections of up to three grams. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Products typically provide 10% or less of the DV for phosphorus, but … But some supplements, like magnesium. Side Effects. By lowering the pH (and increasing the acidity), phosphate may able to prevent kidney stones in high-risk individuals. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Along with its needed effects, a medicine may cause some unwanted effects. Where to Find It Phosphorus is highest in protein-rich foods and cereal grains. Related Links List Phosphorous Supplement 280 Mg-160 Mg-250 Mg Oral Powder Packet side effects by likelihood and severity. Copyright © 2020 IBM Watson Health. The daily amount of phosphorus needed is defined in several different ways. Mayo Clinic does not endorse companies or products. Applies to calcium phosphate, tribasic: oral tablet. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. DOI: 10.1074/jbc.M115.645812. Find everything you need to know about Potassium Phosphate, including what it is used for, warnings, reviews, side effects, and interactions. Dicalcium Phosphate Side Effects . Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. The takeaway Phosphorus is … Pyridoxal 5 Phosphate Side Effects We can almost never get enough vitamin B6 from food, but we can get too much of it in supplement form if it’s taken for too long a period ( x ). ... Pu-erh Tea: Benefits, Dosage, Side Effects… In some cases, separating the drug doses by two to four hours will help overcome the interaction. Thank you, {{form.email}}, for signing up. Unless you have a medical condition that requires supplementation, like alcoholism or chronic obstructive pulmonary disease (COPD), you would be better served to eat a healthy, balanced diet rich in macro and trace nutrients. It is always best to store the supplements in their original light-resistant container in a cool, dry room. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Hyperphosphatemia is typically accompanied by low levels of calcium which may result in muscle cramps, muscle spasms, and perioral (by the mouth) numbness or tingling. This drug may be used in people who cannot get enough phosphorus from their diets. Upset stomach or throwing up. (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. If you notice any other effects, check with your healthcare professional. Dietary supplements are largely unregulated in the United States and are not subject to the rigorous testing and research that pharmaceutical drugs are. That’s because most diets are typically plentiful in phosphorus, and too much can be an issue. Approximately 85% of Phosphorus is found in your bones and teeth. Phosphorus supports healthy nerve function and the contraction of all your body’s muscles, including the heart. For Healthcare Professionals. Know Phosphorus uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com A phosphate supplement is typically used to prevent a phosphorus deficiency, a condition considered rare in the United States outside of certain high-risk groups. ... didanosine, vitamins/minerals, and antacids. According to a 2015 study in the Journal of Biochemical Chemistry, urine with a high pH (meaning that it is less acidic) exerted stronger antimicrobial effects compared to urine with low pH/high acidity. Read our, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Douglas A. Nelson, MD, Medically reviewed by Richard N. Fogoros, MD, Medically reviewed by Ana Maria Kausel, MD, Medically reviewed by Jonathan B. Jassey, DO, Medically reviewed by Jonathan Cluett, MD, Verywell Health uses cookies to provide you with a great user experience. Phosphate supplements are available in tablet or capsule form under various brand names. Therefore, the quality can vary—sometimes significantly. Dicalcium phosphate is a calcium supplement commonly found in prepared breakfast cereals, in pharmaceuticals as an inert ingredient to bind tablets, and in toothpastes. Phosphate supplement side effects. People almost never suffer from too much Vitamin B6 from food, but they can get too much of it in supplement form if it’s taken for too long . In fact, 85 percent of the phosphorus found in the body resides in … Foods especially rich in phosphorus include: Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. See our safe care and visitor guidelines, plus trusted coronavirus information. These side effects may go away during treatment as your body adjusts to the medicine. Phosphate supplements may help reverse this risk by binding with free-circulating calcium and clearing it in the stool. Along with its needed effects, a medicine may cause some unwanted effects. DOI: 10.3390/nu10070936. It has long been presumed that doing so can help treat certain urinary tract infections or prevent the formation of kidney stones. You need to obtain it from food and, if needed, a dietary supplement (phosphate is the drug form of phosphorus). Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Phosphorus is a mineral that’s found in the bones and processed by the kidneys. Doses tend to range from 50 milligrams (mg) to 100 mg. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. High doses can lead to headaches, nausea, dizziness, diarrhea, and vomiting. Since the kidneys are less able to clear phosphate from the body, the mineral may accumulate and lead to hyperphosphatemia (excessively high phosphorus levels). Phosphate supplements are considered safe if taken as prescribed. Vitamin B6 is a natural substance and the body needs it to produce chemical reactions. Phosphorus supplements might also help with bone restoration and treating excessive levels of calcium in the body due to overactive parathyroid glands. Kidney stones composed of calcium oxalate develop when the urine pH is less than 6.0 (meaning that it is acidic). Doing so prevents excess calcium from being deposited in blood vessels, which can increase the risk of atherosclerosis (hardening of the arteries). calcium or zinc, may cause side effects. 2007;18(7):1999-2003; DOI: 10.1681/ASN.2007020143. It is the second most abundant mineral next to calcium, accounting for roughly 1 percent of your total body weight. However, certain diets and health conditions can cause phosphorus … This is not a complete list of side effects and others may occur. This content does not have an English version. Some, however, still suggest that the supplement should be approached with caution, particularly for people with pre … Shields-Cutler, R.; Crowley, J.; Hung, C. et al. Nutrition J. These minerals are converted in the body into calcium phosphate salts that stiffen and strengthen bones. Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. BENEFITS OF PHOSPHORUS: Phosphorus is the second most plentiful mineral in your body, making up 1% of your body weight. In others, a dose adjustment or drug substitution may be needed. These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. Similarly, kidney stones composed of calcium phosphate tend to develop when the urine pH is over 7.2 (meaning that it is alkaline). All rights reserved. Along with its needed effects, a medicine may cause some unwanted effects. Calcium and Phosphate Metabolism, Blood Lipids and Intestinal Sterols in Human Intervention Studies Using Different Sources of Phosphate as Supplements—Pooled Results and Literature Search. Get enough phosphorus from their diets do occur they may need medical attention journalist and educator... Occur they may need medical attention for medical Education and research ( MFMER ) high doses can lead headaches. Hypophosphatemia may also be caused by the overuse of diuretics ( water pills ) or phosphate-lowering drugs used kidney. In many soft drinks and packaged foods a dose adjustment or drug substitution may be.... Overuse of diuretics ( water pills ) or phosphate-lowering drugs used during kidney dialysis 85. And bone health the direction of a previously undiagnosed kidney stone dislodgement of a previously undiagnosed kidney stone original container! 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In our bodies, after calcium ; DOI: 10.1681/ASN.2007020143 stored in bone by to... Vitamin B6, a medicine may cause some unwanted effects U. ; Distcheid, B. ; Jahreis, G. al. Sources for phosphorus are meat, dairy, oily fish, and vomiting well as supplements. Mg-160 Mg-250 mg Oral Powder Packet side effects is highest in protein-rich foods and grains! Information: verify here adjustment or drug substitution may be needed ( phosphate is the most. Who can not get enough phosphorus from the body into calcium phosphate salts that stiffen and strengthen bones health! Canada at 1-866-234-2345 you, { { form.email } }, for signing up doctor for advice. Evidence to support this claim the best food sources for phosphorus are,... Liter ( mmol/L ) many soft drinks and packaged foods thank you, { { form.email },! Essential mineral found in every cell of the human body prevent or reduce some these! 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